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Small RNAs with big implications: new insights into H/ACA snoRNA function and their role in human disease
2014
Wiley Interdisciplinary Reviews - RNA
A myriad of structurally and functionally diverse non-coding RNAs (ncRNAs) have recently been implicated in numerous human diseases including cancer. Small nucleolar RNAs (snoRNAs), the most abundant group of intron-encoded ncRNAs, are classified into two families (box C/D snoRNAs and box H/ACA snoRNAs) and are required for post-transcriptional modifications of ribosomal RNA (rRNA). There is now a growing appreciation that nucleotide modifications on rRNA may impart regulatory potential to the
doi:10.1002/wrna.1266
pmid:25363811
pmcid:PMC4390053
fatcat:mooznxjctbcffev7w53hrhv75i