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In recent years, the increased understanding of the patho physiology of psoriasis has resulted in several new treat ments. The success of ustekinumab proved the importan ce of the IL23/T helper cell 17 axis in psoriatic diseases. Several new biologics targeting this axis will reach the clinic in the next years. Biologics are costly, require in jections, and some patients experience taca phylaxis, thus, the development of orally available, smallmolecu le inhibitors is desirable. Amongdoi:10.2340/00015555-1931 pmid:25111317 fatcat:ftacwnb5dncarjddludhcmwxwy