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To conduct a meta-analysis of the effect of glutamine supplements on prognosis in adult critical-ill patients. We searched the Web of Science, Cochrane library, PubMed, the Wanfang Database, and the China National Knowledge Infrastructure (CNKI)/CBMdisc database. The primary outcome was hospital mortality, or if not reported, 28-day/6-month/intensive care unit (ICU) mortality. The secondary outcomes were duration of mechanical ventilation (MV), length of stay (LOS) in the ICU, LOS in thedoi:10.21037/apm-20-702 pmid:33222464 fatcat:5x25b7bhiva2bhlq3esm4ibjvi