Introduction-purpose: Neural tissue tumors are uncommon in oral cavity easily misdiagnosed as fibroma or other reactive tumorous entities. We report two cases of benign tumors (traumatic neuroma of lip and schwannoma of tongue) of neural origin with diagnostic importance. Case presentation: A 9-year-old girl presented with painless tumorous lesion on the lower lip with 5 months duration and a 50-year-old woman with a painful nodular lesion on the tip of tongue for more than 1 year. Both lesions

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... were initially diagnosed as fibroma but the biopsies after total excision confirmed the diagnosis of traumatic neuroma and schwannoma, respectively. Discussion: The increase of both lesions was slow, and the pain was an important finding in case of Schwannoma. Also, the lesions were located in areas easily traumatized and the surface of mucosa in Schwannoma was not intact. The final diagnosis of intraoral tumorous-like lesion should always include biopsy in order to reveal their exact nature avoiding recurrence. Conclusion: Tumors of neural origin could rarely lead to diagnostic pitfalls in patients of any age. Biopsy and possibly Immunohistochemistry can confirm the nature of such a lesion with impact on therapy and prognosis. Traumatic reactive lesions (fibromas), HPV-related lesions or other benign or malignant tumors could be included in the differential diagnosis.