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CHASMplus Reveals the Scope of Somatic Missense Mutations Driving Human Cancers
2019
Cell Systems
Large-scale cancer sequencing studies of patient cohorts have statistically implicated many genes driving cancer growth and progression, and their identification has yielded substantial translational impact. However, a remaining challenge is to increase the resolution of driver prediction from the level of genes to mutations because mutation-level predictions are more closely aligned with the goal of precision cancer medicine. Here, we present CHASMplus, a computational method that is uniquely
doi:10.1016/j.cels.2019.05.005
pmid:31202631
pmcid:PMC6857794
fatcat:5kznuxeiunfghjb7bwvaoe3kzm