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Exploring Biased Agonism at FPR1 as a Means to Encode Danger Sensing
Ligand-based selectivity in signal transduction (biased signaling) is an emerging field of G protein-coupled receptor (GPCR) research and might allow the development of drugs with targeted activation profiles. Human formyl peptide receptor 1 (FPR1) is a GPCR that detects potentially hazardous states characterized by the appearance of N-formylated peptides that originate from either bacteria or mitochondria during tissue destruction; however, the receptor also responds to several non-formylateddoi:10.3390/cells9041054 pmid:32340221 fatcat:rgt7tq7l6ffv3jetcsmaxfflla