Synergy effect of Ceftazidime-Avibactam with Meropenem against pan-resistant Acinetobacter baumannii and Serratia marcescens harboring carbapenemases: time-kill and disk approximation assays

Juliana Januário Gaudereto, Lauro Vieira Perdigão Neto, Gleice Cristina Leite, Roberta Ruedas Martins, Gladys Villas Boas do Prado, Flavia Rossi, Thais Guimarães, Anna Sara Levin, Silvia Figueiredo Costa
2019 Antimicrobial Agents and Chemotherapy  
Susceptibility of ceftazidime/avibactam and in vitro synergy with meropenem using disk approximation and time-kill assays were investigated against eleven multiresistant Acinetobacter baumannii harboring oxacillinases and five Serratia marcescens carrying blaKPC-2. Ceftazidime/avibactam was very active and synergistic with meropenem against multiresistant S. marcescens isolates. On the other hand, only A. baumannii isolates co-harboring blaOXA-23 and blaOXA-117 displayed synergy. The disk
more » ... rgy. The disk approximation technique presented good sensitivity for synergism in S. marcescens.
doi:10.1128/aac.02367-18 fatcat:jhk33wlaifbc7drkidwmqq3r4i