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Inositol-requiring Enzyme 1 Inhibits Respiratory Syncytial Virus Replication
2014
Journal of Biological Chemistry
The endoplasmic reticulum (ER) stress response is increasingly implicated in the pathogenesis of viral infections. Results: Respiratory syncytial virus (RSV) infection induces the inositol-requiring enzyme 1 (IRE1) stress pathway. IRE1 activity inhibits RSV replication. Conclusion: ER stress may be a novel cellular anti-RSV defense mechanism. Significance: Identification of a novel regulator of RSV replication may have therapeutic implications. . 2 The abbreviations used are: RSV, respiratory
doi:10.1074/jbc.m113.510594
pmid:24497642
pmcid:PMC3953267
fatcat:aouvvfsrlnga7c7aez6ccd6nv4