Inositol-requiring Enzyme 1 Inhibits Respiratory Syncytial Virus Replication

Ihab Hassan, Kayla S. Gaines, Wesley J. Hottel, Ryan M. Wishy, Sara E. Miller, Linda S. Powers, D. Thomas Rutkowski, Martha M. Monick
2014 Journal of Biological Chemistry  
The endoplasmic reticulum (ER) stress response is increasingly implicated in the pathogenesis of viral infections. Results: Respiratory syncytial virus (RSV) infection induces the inositol-requiring enzyme 1 (IRE1) stress pathway. IRE1 activity inhibits RSV replication. Conclusion: ER stress may be a novel cellular anti-RSV defense mechanism. Significance: Identification of a novel regulator of RSV replication may have therapeutic implications. . 2 The abbreviations used are: RSV, respiratory
more » ... ncytial virus; ER, endoplasmic reticulum; PERK, protein kinase R-like ER kinase; ATF, activated transcription factor; BiP, binding immunoglobulin protein; XBP, X box binding protein; ab, antibody; MOI, multiplicity of infection; MEF, mouse embryonic fibroblast; HTBE, human tracheobronchial epithelial.
doi:10.1074/jbc.m113.510594 pmid:24497642 pmcid:PMC3953267 fatcat:aouvvfsrlnga7c7aez6ccd6nv4