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Altered transcription factor binding events predict personalized gene expression and confer insight into functional cis-regulatory variants
[article]
2017
bioRxiv
pre-print
Deciphering the functional roles of cis-regulatory variants is a critical challenge in genome analysis and interpretation. We hypothesize that altered transcription factor (TF) binding events are a central mechanism by which cis-regulatory variants impact gene expression. We present TF2Exp, the first gene-based framework (to our knowledge) to predict the impact of altered TF binding on personalized gene expression based on cis-regulatory variants. Using data from lymphoblastoid cell lines,
doi:10.1101/228155
fatcat:donvrza57bdzll4nyinjcioaxy