Synthesis, Characterization and DNA-Binding Properties of the Cu(II) Complex with 7-Methoxychromone-3-carbaldehyde-benzoylhydrazone

Gao-Fei Qi, Zheng-Yin Yang, Dong-Dong Qin
2009 Chemical and pharmaceutical bulletin  
A new chromone derivative (7-methoxychromone-3-carbaldehyde-benzoylhydrazone) ligand (HL) and its novel Cu(II) complex have been synthesized and characterized on the basis of elemental analyses, molar conductivities, proton nuclear magnetic resonance, infrared spectra and mass spectra analyses. The general formula of the Cu(II) complex is [CuL(HB 2B O)]Cl · 2H 2 O. In addition, the interaction of the Cu(II) complex and its free ligand with calf-thymus DNA was investigated by electronic
more » ... electronic absorption spectroscopy, fluorescence spectroscopy and viscosity measurement. Results suggest that both the two compounds can bind with calf-thymus DNA via an intercalation mechanism. Furthermore, the Cu(II) complex can bind to DNA more strongly than the free ligand due to the chelating effect of copper(II) ion to the free ligand.
doi:10.1248/cpb.57.69 pmid:19122319 fatcat:2ql5ip7evnc7naml6neojciqsa