CSH guidelines for the diagnosis and treatment of drug-induced liver injury

Yue-cheng Yu, Yi-min Mao, Cheng-wei Chen, Jin-jun Chen, Jun Chen, Wen-ming Cong, Yang Ding, Zhong-ping Duan, Qing-chun Fu, Xiao-yan Guo, Peng Hu, Xi-qi Hu (+24 others)
2017 Hepatology International  
Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. It can be induced by small chemical molecules, biological agents, traditional Chinese medicines (TCM), natural medicines (NM), health products (HP), and dietary supplements (DS). Idiosyncratic DILI is far more common than intrinsic DILI clinically and can be classified into hepatocellular injury, cholestatic injury, hepatocellular-cholestatic mixed injury, and vascular injury
more » ... ased on the types of injured target cells. The CSH guidelines summarized the epidemiology, pathogenesis, pathology, and clinical manifestation and gives 16 evidence-based recommendations on diagnosis, differential diagnosis, treatment, and prevention of DILI.
doi:10.1007/s12072-017-9793-2 pmid:28405790 pmcid:PMC5419998 fatcat:wry7nx4lgfcxxentyupnvpajfu