AIM: To observe the effectiveness and safety of the active-fluidics configuration with Centurion phacoemulsifier in cataract surgery.METHODS: One hundred and thirty-three eyes with Ⅱ-Ⅳ grades cataracts were enrolled in this randomized prospective study from October to December 2018. They were divided into two groups, the experimental group used active-fluidics configuration for cataract surgery, while the control group used gravity-fluidics configuration. Cumulative dissipated energy(CDE),

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... ation time(AT)and estimated fluid used(EFU)of each patient were recorded during the operation, endothelial cell density(ECD)and central corneal thickness(CCT)were measured before and one day after operation.RESULTS: The CDE, AT and EFU were significantly lower with the active-fluidics configuration than with the gravity-fluidics configuration(P<0.05); ECD was slightly decreased and CCT was slightly increased in both groups 1d after operation, but there was no difference between the two groups(2056.06±308.10cells/mm2 vs 1997.26±297.55cells/mm2, 532.75±12.02μm vs 531.02±13.00μm; P>0.05). No serious ocular adverse events related to the study devices or device deficiencies were observed.CONCLUSION:Centurion active-fluidics configuration can maintain constant intraocular pressure during the operation, improve the stability of anterior chamber effectively. So it is safer and more efficient than traditional gravity-fluidics configuration.