Virilization of a Young Girl Caused by Concomitant Ectopic and Intra-Adrenal Adenomas of the Adrenal Cortex

Daniela Choukair, Felix Beuschlein, Oliver Zwermann, Stefan A. Wudy, Sabine Haufe, Stefan Holland-Cunz, Markus Bettendorf
2013 Hormone Research in Paediatrics  
testosterone and dehydroepiandrosterone were elevated. Androgens remained unchanged after adrenocorticotropic hormone, and dexamethasone administrations. Ultrasound examination and magnetic resonance imaging indicated an extra-adrenal mass adjacent to the left adrenal gland, which was removed by endoscopic surgery. However, plasma androgens remained elevated and 131 I-iodomethyl-norcholesterol scintigraphy revealed tracer enhancement in the right adrenal gland, which was consecutively removed.
more » ... irilization regressed after extirpation of the adenomas and height Abstract Background: Adenomas of the adrenal gland are rare causes of virilization in childhood. Case Report: A girl aged 2 years and 4 months presented with pubarche, distinct clitoral hypertrophy, tall stature, and increased height velocity. Plasma
doi:10.1159/000350244 pmid:23711916 fatcat:xd7v7xwdujbath5yeq4mjea7yi