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Optical Resolution of Rimantadine
2019
Molecules
Preserved Fulltext
This work discloses a new procedure for the resolution of commercially available racemic rimantadine hydrochloride to enantiomerically pure (S)-rimantadine using (R)-phenoxypropionic acid as a recyclable resolving reagent. Good chemical yields, operational ease, and low-cost structure underscore the preparative value of this method for the production of enantiomerically pure rimantadine for medicinal or synthetic studies.
doi:10.3390/molecules24091828
pmid:31083636
pmcid:PMC6539882
fatcat:553qibp46jdynkwvhni5iio3vm