Quantification and visualization of defects of the functional dopaminergic system using an automatic algorithm

J B Habraken, J Booij, P Slomka, E B Sokole, E A van Royen
1999 Journal of Nuclear Medicine  
The method presented quantifies [123I]FPCIT binding ratio automatically on a voxel-by-voxel basis, by comparison with a model of healthy volunteers. We have shown that it is appropriate to use the automatic method as a replacement for the traditional manual method, which enables us to study the localized dopaminergic degeneration process in Parkinson's disease more precisely and without any inter- or intraobserver variability.
pmid:10405125 fatcat:sqtzt6qsx5evfc7g5jc4um57f4