Quantification and visualization of defects of the functional dopaminergic system using an automatic algorithm

J B Habraken, J Booij, P Slomka, E B Sokole, E A van Royen
1999 Journal of Nuclear Medicine  
In SPECT, the binding of radiotracers in brain areas is usually assessed by manual positioning of regions of interest (ROIs). The disadvantages of this method are that it is an observer-dependent procedure and that it may not be sensitive for assessing defects significantly smaller than the ROI. To circumvent these limitations, we developed a fully automatic three-dimensional technique that quantifies neuronal radiotracer binding on a voxel-by-voxel basis.
pmid:10405125 fatcat:sqtzt6qsx5evfc7g5jc4um57f4