Dynamics of proteins in solution

Marco Grimaldo, Felix Roosen-Runge, Fajun Zhang, Frank Schreiber, Tilo Seydel
2019 Quarterly Reviews of Biophysics (print)  
The dynamics of proteins in solution includes a variety of processes, such as backbone and side-chain fluctuations, interdomain motions, as well as global rotational and translational (i.e. center of mass) diffusion. Since protein dynamics is related to protein function and essential transport processes, a detailed mechanistic understanding and monitoring of protein dynamics in solution is highly desirable. The hierarchical character of protein dynamics requires experimental tools addressing a
more » ... road range of time- and length scales. We discuss how different techniques contribute to a comprehensive picture of protein dynamics, and focus in particular on results from neutron spectroscopy. We outline the underlying principles and review available instrumentation as well as related analysis frameworks.
doi:10.1017/s0033583519000027 fatcat:n25mwyf7trgfvfxmx4no7jby7q