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Stimulation of P2X7Receptors Elevates Ca2+and Kills Retinal Ganglion Cells
Investigative Ophthalmology and Visual Science
PURPOSE. Retinal ganglion cells are known to express ionotropic P2X 7 receptors for ATP. Stimulation of these receptors in other cells can elevate Ca 2ϩ and sometimes lead to cell death. This study asked whether P2X 7 receptor stimulation alters the Ca 2ϩ levels and viability of retinal ganglion cells. METHODS. P2X 7 agonists were applied to retinal ganglion cells from neonatal rats loaded with fura-2 to examine their effect on intracellular Ca 2ϩ levels. The effect of P2X 7 receptordoi:10.1167/iovs.05-0052 pmid:15914640 fatcat:udnvmqduvfbfpck5guj5o4scwu