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Mutagenesis of p22phoxHistidine 94
2002
Journal of Biological Chemistry
The NADPH oxidase is a multicomponent enzyme that transfers electrons from NADPH to O 2 to generate superoxide (O 2 . ), the precursor of microbicidal oxygen species that play an important role in host defense. Flavocytochrome b 558 , a heterodimeric oxidoreductase comprised of gp91 phox and p22 phox subunits, contains two nonidentical, bis-histidine-ligated heme groups imbedded within the membrane. Four histidine residues that appear to serve as noncovalent axial heme ligands reside within the
doi:10.1074/jbc.m203993200
pmid:12042318
fatcat:ci4v2dvoonfuxjnssxaigjoomy