Rapid uptake of dietary cholesterol by hyperplastic liver nodules and primary hepatomas

B J Horton, G E Mott, H C Pitot, S Goldarb
1973 Cancer Research  
Hyperplastic liver nodules and primary hepatomas induced by 2-acetylaminofluorene take up cholesterol-3 H, given p.o., at a rate only slightly less than that in normal liver, and 10-to 30-fold greater than that reported for transplantable hepatomas. In the case of primary hepatomas, the rate of uptake appeared to be related to the degree of differentiation and hence a function of tumor progression. Previous studies on regulation of cholesterol synthesis in primary hepatomas and cholesterol
more » ... e studies in transplantable hepatomas may need to be reinterpreted in view of these results.
pmid:4347713 fatcat:v3kjau2bmzhjnczdjbz4chb4qy