A facile and practical p-Toluenesulfonic acid catalyzed route to dicoumarols containing an Aroyl group

Saeed KHODABAKHSHI, Bahador KARAMI, Khalil ESKANDARI, Alimorad RASHIDI
2015 South African Journal of Chemistry  
New and known dicoumarols may be efficiently synthesized employing p-toluenesulfonic acid (p-TSA) as a solid acid catalyst from the reaction of 4-hydroxycoumarin with aryl glyoxal in water. This method offers direct access to structurally diverse coumarin derivatives in moderate to good yields (up to 65%). A total of five new compounds were synthesized. KEYWORDS Dicoumarol, p-toluenesulfonic acid, aryl glyoxal, 4-hydroxycoumarin.
doi:10.17159/0379-4350/2015/v68a8 fatcat:6qal6coduzglbmm2a3c2egccgi