Estimation of blood antimicrobial peptide levels in women of reproductive age with pelvic inflammatory disease before and after antibiotic therapy
Оценка уровня антимикробных пептидов в крови у женщин репродуктивного возраста с воспалительными заболеваниями органов малого таза до и после антибактериальной терапии

Vladimir Baturin, Roberta Boshyan
2021 Medical news of the North Caucasus  
Blood α-defensin-1 (DEFa1) and β-defensin-1 (DEFb1) levels in 56 women of reproductive age with pelvic inflammatory disease were evaluated before and after antibiotic therapy. DEFa1 levels were decreased by 20 % after tetracycline monohydrate therapy (n=22), by 15.6 % after levofloxacin therapy (n=18), and by 25 % after josamycin therapy (n=16) compared with before therapy. DEFb1 levels were increased by 17 % after tetracycline monohydrate therapy, by 45 % after josamycin therapy, and by 80 %
more » ... ter levofloxacin therapy compared with before therapy. Our study shows that blood antimicrobial peptide levels in women with pelvic inflammatory disease are different and depend on the antibacterial drug used.
doi:10.14300/mnnc.2021.16035 fatcat:igdddjd2ubejblqwnbdih5f33e