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Toxicity of Carboplatin vs. Cisplatin
白金抗癌剤 carboplatin の毒性に関する実験的研究

Iwao Ohtani, Tomohiro Anzai, Tohru Aikawa, Hiro-oki Okamura
1989 Practica oto-rhino-laryngologica Suppl  

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The ototoxicity, nephrotoxicity and hematologic toxicity of carboplatin (CBDCA) were compared with those of cisplatin (CDDP) using the rat and guinea pig. The oto-and nephrotoxicity of CBDCA was very low as compared with CDDP. Forced hydration and diuresis will not be necessary for CBDCA administration clinically. The hematologic toxicity was remarkably high in comparison to CDDP. The dose limiting toxicity of CBDCA will be primarily bone marrow suppression. The excretion of CBDCA from the bone
more » ... marrow as well as serum, perilymphatic space, kidney was extremely fast. In conclusion the difference of severity of various toxicity induced by CBDCA is not only due to the concentration in the tissues.
doi:10.5631/jibirinsuppl1986.1989.supplement32_49 fatcat:dlqr5owwzzhgfbebxnid6mu2ra
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Iwao Ohtani, Tomohiro Anzai, Tohru Aikawa, Hiro-oki Okamura. "Toxicity of Carboplatin vs. Cisplatin." Practica oto-rhino-laryngologica Suppl 1989.Supplement32 (1989) 49-55