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Real-time integration of cell death and proliferation kinetics at the single-cell and population-level using high-throughput live-cell imaging
SummaryQuantifying cytostatic and cytotoxic outcomes are integral components of characterizing perturbagens used as research tools and/or in drug discovery pipelines. Furthermore, data-rich acquisition coupled with robust methods for analysis is required to properly assess the function and impact of these perturbagens. Here, we present a detailed and versatile method for Single-cell and Population-level Analyses using Real-time Kinetic Labeling (SPARKL). SPARKL integrates high-content live-celldoi:10.1101/596239 fatcat:qoe5tea2r5dhdcy4itjtuguiwy