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Comprehensive characterisation of cell-free tumour DNA in plasma and urine of patients with renal tumours
[article]
2019
bioRxiv
pre-print
Cell-free tumour-derived DNA (ctDNA) allows non-invasive monitoring of cancers but its utility in renal cell cancer (RCC) has not been established. Here, untargeted and targeted sequencing methods, applied to two independent cohorts of renal tumour patients (n=90), were used to determine ctDNA content in plasma and urine. Our data revealed lower plasma ctDNA levels in RCC relative to other cancers, with untargeted detection of ~33%. A sensitive personalised approach, applied to plasma and urine
doi:10.1101/758003
fatcat:cjcnibdzija4dao62hxyrpeb7a