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Cytochrome P-450 (P450) catalyzes a wide variety of chemical reactions; however, its use for in vitro assays has several limitations, the most striking one is the use of the reduced nicotinamide adenine dinucleotide phosphate (NADPH) coenzyme. In this work, the P450 activity using NADP + reduced by an anionic organosiloxane, commonly named silica hydride, was evaluated. The results showed that the reduction of NADP + with silica hydride was concentration-and time-dependent. P-450 activity wasdoi:10.3797/scipharm.0803-01 fatcat:agx322x5wfaf7knvxzkwk6gwxm