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Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
Experimentally-verified information on protein function lags far behind the rapid accumulation of protein sequences. The simple approach to propagating information from characterized proteins to unknown proteins-namely, by sequence similarity search against databases of individual proteins-may fail to produce accurate results, and typically is used to transfer only protein name information. A more accurate, consistent, and comprehensive approach for largescale automated annotation makes use ofdoi:10.1002/047001153x.g403314 fatcat:lhwkwad26zcttpgw5be2h5eijq