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Proteases play prominent roles in many physiological processes and the pathogenesis of various diseases, which makes them interesting drug targets. To fully understand the functional role of proteases in these processes, it is necessary to characterize the target specificity of the enzymes, identify endogenous substrates and cleavage products as well as protease activators and inhibitors. The complexity of these proteolytic networks presents a considerable analytic challenge. To comprehensivelydoi:10.1002/pmic.201100399 pmid:22246865 pmcid:PMC3431026 fatcat:p5bsupjguvgmthjmkp3rkjcbjm