Effect of Mao-Bushi-Saishin-To on Nasal Allergy with Nasal Obstruction

Hirotaka Ito, Shunkichi Baba, Ippei Takagi, Yasuhiko Ohya
1991 Practica oto-rhino-laryngologica Suppl  
Mao-bushi-saishin-to extract capsules (6 caps./day) were administered orally to 61 perennial nasal allergy patients presenting with nasal obstruction for 4 consecutive weeks to assess the overall efficacy, safety and utility of the drug. In the doctor's evaluation, the overall efficacy rate covering excellent and good responses was 38.3% at week 2 of treatment and 54.7% at week 4 of treatment. The utility rate covering useful and higher ratings was 60.7%. Nasal symptoms, viz, sneezing attack,
more » ... sal discharge, nasal obstruction, dysosmia and interference with daily living were all improved. Nasal obstruction, in particular, disappeared in many cases, thus generating a high improvement rate. Nasal mucosal findings, viz, swelling of inferior turbinal mucosa, watery secretion in nasal cavity, and nasal discharge eosinophil count showed good improvements. The time course of each nasal symptom in terms of the average score according to allergy diaries, revealed significant reduction in nasal obstruction, dysosmia and interference with daily life in severity at and after week 2 and sneezing and nasal discharge were significantly alleviated at week 4 as compared with the findings obtained during the baseline period. As side effects, headache was reported in one case and stomachache in one case. These symptoms were relieved after discontinuation of treatment.
doi:10.5631/jibirinsuppl1986.1991.supplement52_107 fatcat:ysnmtbe4crgi3eqhpgih3yvogm