Evaluation of vascular healing of polymer-free sirolimus-eluting stents in native coronary artery stenosis: a serial follow-up at three and six months with optical coherence tomography imaging
Pannipa Suwannasom, Yoshinobu Onuma, Edouard Benit, Olivier Gach, Clemens von Birgelen, Sjoerd H. Hofma, Yohei Sotomi, Xu Bo, Yao-Jun Zhang, Runlin Gao, Hector M. García-García, Joanna J. Wykrzykowska
(+2 others)
2016
EuroIntervention
Aims: Our aim was to assess vascular response after polymer-free sirolimus-eluting stent (SES) implantation by using an optical coherence tomography (OCT)-derived vascular healing score (HS), quantifying the deficiency of healing. Methods and results: In a prospective, multicentre, single-arm, open-label study, OCT examinations were performed at three months in 45 patients (47 lesions). Per protocol, 24 lesions which had not reached adequate vascular healing according to study criteria were
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... duled for OCT examination at six months. The HS was calculated at two time points. Serial OCT imaging demonstrated that the proportion of covered stent struts increased from a median of 87.1% at three months to 98.6% at six months (p<0.001). The neointimal thickness increased from a median of 82.8 µm to 112.2 µm (p<0.001), whereas the median percentages of malapposed struts were 0.2% and 0.0% at the two respective time points. Neointimal volume obstruction increased from 6.3% to 12.8%, and the HS decreased from a median of 28.1 at three months to 2.4 at six months. Conclusions: In patients who had inadequate vascular healing three months after polymer-free SES implantation, serial OCT showed almost complete vascular healing at six months. (ClinicalTrials.gov Identifier: NCT01925027) KEYWORDS • drug-eluting stent • healing score • optical coherence tomography (OCT) • polymer-free SUBMITTED ON 25/09/2015 -REVISION RECEIVED ON 02/12/2015 -ACCEPTED ON 23/12/2015 e 575 EuroIntervention 2016;12:e574-e583 Nano+ OCT study Abbreviations BMS bare metal stent DAPT dual antiplatelet therapy DES drug-eluting stent HS healing score ISA incomplete stent apposition LLL late lumen loss OCT optical coherence tomography %NVO percentage of in-stent neointimal volume obstruction RUTTS ratio of uncovered to total stent struts per section SES sirolimus-eluting stent
doi:10.4244/eijv12i5a97
pmid:27497357
fatcat:y5nqqhh5kbcajmdwc3oendtuh4
