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Importance of the Amino Acid in Position 15 of VIP and Secretin in Influencing their Interactions with Membrane Receptors on Pancreatic Acinar Cells
Synopsis To explore the importance of the charge of the amino acid in position 15 in influencing the apparent affinities of VIP and secretin for their receptors on pancreatic acinar cells, we tested the synthetic C-terminal 23-peptide fragment of secretin (S5-27) and two analogues containing substitutions in position 15 for their abilities to interact with secretin-preferring and VIP-preferring receptors on pancreatic acinar cells. In inhibiting the increase in cyclic AMP caused by VIP actingdoi:10.1507/endocrj1954.27.supplement_1 pmid:6262063 fatcat:da6c3uygv5dajhln6envhayoze