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Is the Extrapolated Adult Dose of Fosinopril Safe and Effective in Treating Hypertensive Children?
We evaluated the efficacy, safety, and dose-response relationship of fosinopril in children aged 6 to 16 years with hypertension or high-normal blood pressure with an associated medical condition requiring treatment. The study was a prospective, double-blind, placebo-controlled trial conducted in 78 clinical sites in the United States, Russia, and Israel. There were 4 phases: a screening phase of 10 days maximum, a 4-week dose-response phase, a placebo withdrawal phase of 2 weeks maximum, and adoi:10.1161/01.hyp.0000138069.68413.f0 pmid:15262902 fatcat:7gts2u42efdnfhe3eo7ggb6umu