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Acute Liver Injury by Vinyl Chloride: Involvement of Endoplasmic Reticulum in Phenobarbital-Pretreated Rats
1975
Environmental Health Perspectives
Preserved Fulltext
A single 6-hr exposure to vinyl chloride monomer (5%o) produces extensive vacuolization of centrolobular liver parenchyma and focal midzonal necrosis in the hepatic lobuole in phenobarbital-pretreated rats. Ultrastructurally, vacuolization consists of dilation of cysternae of rough endoplasmic reticulum and in the same cells smooth endoplasmic reticulum coalesces into discreet aggregates resembling denatured membranes. The findings support the hypothesis that vinyl chloride is hepatotoxic
doi:10.2307/3428348
fatcat:ooibjbxu6nejfcbvpyg6vqk6ii