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Pregnane X receptor exacerbates nonalcoholic fatty liver disease accompanied by obesity- and inflammation-prone gut microbiome signature
Pregnane X receptor (PXR) is a drug receptor with novel functions in promoting non-alcoholic fatty liver disease (NAFLD). We hypothesize that PXR worsens NAFLD accompanied by gut dysbiosis. Wild-type and PXR-knockout mice were fed control or high fat diet (HFD) for 16-weeks. Serum parameters, liver histopathology, transcriptomic profiling, 16S-rDNA sequencing, and bile acid (BA) metabolomics were performed. PXR enhanced HFD-induced weight gain, hepatic steatosis and inflammation especially indoi:10.21203/rs.3.rs-134429/v1 fatcat:yteycxby75gb3p7txp7k6krqbe