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Mechanisms of suppression of neoplastic transformation in vitro by low doses of low LET radiation
Suppression of neoplastic transformation of HeLa skin fibroblast human hybrid cells in vitro following low doses of low linear energy transfer radiation has been reported previously. The present study represents an exploration of two hypothesized mechanisms that may underlie this observed suppression. These are the up-regulation of reduced glutathione (GSH), a known antioxidant, and induction of DNA repair activity. The hybrid cells were found to have a high endogenous level of GSH and nodoi:10.1093/carcin/bgg172 pmid:14514653 fatcat:r344qbedi5ck3finohxixqnpre