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Detrending RR series is a common processing step prior to HRV analysis. Customarily, RR series, which are inherently unevenly sampled, are interpolated and uniformly resampled, thus introducing errors in subsequent HRV analysis. We have recently proposed a novel approach to detrending unevenly sampled series, which is based on the notion of weighted quadratic variation reduction. In this paper, we extensively assess its performance on RR series through a statistical analysis. Numerical resultsdoi:10.1109/embc.2015.7319106 pmid:26737006 dblp:conf/embc/FasanoV15 fatcat:ghl6c5qipjgitkocigo6eyerqu