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Single-particle imaging (SPI) with X-ray free-electron lasers has the potential to change fundamentally how biomacromolecules are imaged. The structure would be derived from millions of diffraction patterns, each from a different copy of the macromolecule before it is torn apart by radiation damage. The challenges posed by the resultant data stream are staggering: millions of incomplete, noisy and un-oriented patterns have to be computationally assembled into a three-dimensional intensity mapdoi:10.1107/s1600576716008165 pmid:27504078 pmcid:PMC4970497 fatcat:epzyqju5g5dgrf6sfx7d4ip3my