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γδ T cells are distributed in various lymphoid and nonlymphoid tissues, and act as early responders in many conditions. Previous studies have proven their significant roles in infection, cancer, autoimmune diseases and tissue maintenance. Recently, accumulating researches have highlighted the crosstalk between γδ T cells and nervous systems. In these reports, γδ T cells maintain some physiological functions of central nervous system by secreting interleukin (IL) 17, and neurons like nociceptorsdoi:10.3389/fimmu.2021.656097 pmid:33868300 pmcid:PMC8044362 fatcat:rfximpebwzeu7l3a7a2nnsbje4