A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is
KR-31761, a Novel K+ATP-Channel Opener, Exerts Cardioprotective Effects by Opening Both Mitochondrial K+ATP and Sarcolemmal K+ATP Channels in Rat Models of Ischemia/Reperfusion-Induced Heart Injury
Journal of Pharmacological Sciences
The cardioprotective effects of KR-31761, a newly synthesized K + ATP opener, were evaluated in rat models of ischemia / reperfusion (I/ R) heart injury. In isolated rat hearts subjected to 30-min global ischemia / 30-min reperfusion, KR-31761 perfused prior to ischemia significantly increased both the left ventricular developed pressure (% of predrug LVDP: 17.8, 45.1, 54.2, and 62.6 for the control, 1 μM, 3 μM, and 10 μM, respectively) and double product (DP: heart rate × LVDP; % of predrugdoi:10.1254/jphs.08132fp pmid:19234365 fatcat:4qa5jxp6k5gvvpdilib74z3xme