6. Targeted Gene Delivery and Expression in Hepatocytes [chapter]

1997 Concepts in Gene Therapy  
Parenchymal liver cells are the only cells of the adult mammalian body that possess of large numbers of high affinity cell-surface receptors that can recognize galactoseterminal (asialo-) glycoproteins (1, 2). Binding of an asialoglycoprotein by the receptor leads to internalization of the ligand-receptor complex in membrane-bound vesicles, endosomes. Subsequently, acidification of the endosomes results in segregation of the ligand from the receptor. The latter is usually transported to
more » ... nsported to lysosomes where degradation occurs (3).
doi:10.1515/9783110808636-007 fatcat:lldpocgjkjaxjoiodlcpsqp7zy