Dosimetry in Peptide radionuclide receptor therapy: a review

Marta Cremonesi, Mahila Ferrari, Lisa Bodei, Giampiero Tosi, Giovanni Paganelli
2006 Journal of Nuclear Medicine  
The potential of targeted therapy with radiolabeled peptides has been reported in several clinical trials. Although there have been many improvements in dose estimation, a general and reliable dosimetric approach in peptide receptor radionuclide therapy (PRRT) is still a matter of debate. This article reviews the methods for PRRT dosimetry and the results presented in the literature. Radiopharmaceutical characteristics, data processing, dosimetric outcomes, and methods to protect critical
more » ... tect critical organs are reported. The biological effective dose, based on the linear quadratic model, is also described.
pmid:16954555 fatcat:h7qykicveffahab5jtle3nh2am