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An alternative approach to multiple testing for methylation QTL mapping reduces the proportion of falsely identified CpGs
Computer applications in the biosciences : CABIOS
An increasing number of studies investigates the influence of local genetic variation on DNA methylation levels, so-called in cis methylation quantitative trait loci (meQTLs). A common multiple testing approach in genome-wide cis meQTL studies limits the false discovery rate (FDR) among all CpG-SNP pairs to 0.05 and reports on CpGs from the significant CpG-SNP pairs. However, a statistical test for each CpG is not performed, potentially increasing the proportion of CpGs falsely reported on.doi:10.1093/bioinformatics/btu654 pmid:25282645 fatcat:isam7v4pavd3vipm2axydljbkq