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Objective: To estimate the occurrence of acute events in hospitalized patients with sickle cell anemia (SCA) before and after the use of hydroxyurea (HU). Method: The study has a quantitative approach, of analytical cohort type developed in two public referral hospitals in the Midwest region of Brazil Results: The sample had 32 medical records of hospitalized patients diagnosed with SCA who used HU. The mean age of the participants was 25.65±11.92; the average time of drug exposure was 6.0±2.8doi:10.3823/2220 fatcat:u2rrbhv33bgb3lrv5orrrpltka