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Tissue-factor pathway inhibitor and lipoproteins. Evidence for association with and regulation by LDL in human plasma
Arteriosclerosis and Thrombosis A Journal of Vascular Biology
Tissue-factor pathway inhibitor (TFPI) is a potent inhibitor of extrinsic coagulation, which is mainly associated with lipoproteins in circulating blood. Gel filtration of human plasma confirmed the presence of three peaks in which approximately 10%, 70%, and 20% of total TFPI activity was retained. Precipitation of very-low-density lipoproteins and low-density lipoproteins (LDLs) in plasma by polyethylene glycol almost completely abolished peaks I and II. LDL isolated by ultracentrifugationdoi:10.1161/01.atv.14.2.223 fatcat:uxexty7h7baxffyhombdhmwypa