Clinical Implications and Impact of Discovery of the Thyroid Hormone Receptor on Integrin αvβ3–A Review

Aleck Hercbergs
2019 Frontiers in Endocrinology  
Hypothyroidism has been reported to improve survival in cancer patients but only recently has the putative mechanism been identified as a receptor for thyroxine and tri-iodothyronine on integrin αvβ3. Recognition of divergence of action of the pro-oncogenic L-thyroxine (T4) from pro-metabolic 3,5,3 ′ -triiodo-L-thyronine (T3) has enabled clinical implementation whereby exogenous T3 may replace exogenous (or endogenous) T4 to maintain clinical euthyroid hypothyroxinemia that results in
more » ... tly better survival in advanced cancer patients without the morbidity of clinical hypothyroidism.
doi:10.3389/fendo.2019.00565 fatcat:llqkrcigkjdcjicy4wlrmo3pwa