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Trophoblast Stem Cells Rescue Placental Defect in SOCS3-deficient Mice
Journal of Biological Chemistry
Stem cells have important clinical and experimental potentials. Trophoblast stem (TS) cells possess the ability to differentiate into trophoblast subtypes in vitro and contribute to the trophoblast lineage in vivo. Suppressor of cytokine signaling 3 (SOCS3) is a negative regulator of cytokine signaling. Targeted disruption of SOCS3 revealed embryonic lethality on E12.5; it was caused by placental defect with enhanced leukemia inhibitory factor receptor signaling. A complementation of thedoi:10.1074/jbc.c600015200 pmid:16517610 fatcat:63qvplxu3bec5abh6huq2vwc54