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Circadian Clock Regulation of the Secretory Pathway
Proteins destined for secretion move from the endoplasmic reticulum (ER, the site of synthesis) to Golgi cisternae then to the cell surface in transport vesicles. Although the mechanism of anterograde and retrograde transport via vesicles is well understood the temporal coordination of transport between organelles has not been studied. Here we show that the extracellular levels of collagen-I (the most abundant secreted protein in vertebrates) are rhythmic over a 24-hour cycle in tendon, thedoi:10.1101/304014 fatcat:z7ysg57qj5cttjga4i7kb3qvfm