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Comparison of next-generation sequencing samples using compression-based distances and its application to phylogenetic reconstruction
2014
BMC Research Notes
Enormous volumes of short reads data from next-generation sequencing (NGS) technologies have posed new challenges to the area of genomic sequence comparison. The multiple sequence alignment approach is hardly applicable to NGS data due to the challenging problem of short read assembly. Thus alignment-free methods need to be developed for the comparison of NGS samples of short reads. Recently, new k-mer based distance measures such as CVTree, d_2^S, co-phylog have been proposed to address this
doi:10.1186/1756-0500-7-320
pmid:24886411
pmcid:PMC4057587
fatcat:jebuhaqexvf4zjdissfiy5tgqm