A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf
.
The effects of chromatin organization on variation in mutation rates in the genome
2015
Nature reviews genetics
The variation in local rates of mutations can affect both the evolution of genes and their function in normal and cancer cells. Deciphering the molecular determinants of this variation will be aided by resolving distinct types of mutation, since they differ in regional preferences and in associations with genomic features. Chromatin organization contributes to regional variation in mutation rate, but differently among mutation types. In both germ-line mutations and somatic mutations, base
doi:10.1038/nrg3890
pmid:25732611
pmcid:PMC4500049
fatcat:c5dxtkn2orh23e7mlyaecndoce