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The objective of this study was to investigate the possible regulation of the vitamin K-dependent matrix Gla (y-carboxyglutamic acid) protein (MGP) by retinoic acid, a regulation suggested by the recent observation that the human MGP promoter has a perfect direct repeat which is nearly identical to the retinoic acid-responsive element in the retinoic acid receptor-@ gene. We report that retinoic acid strongly increases MGP mRNA levels in all human cells tested, including osteoblasts, articulardoi:10.1210/en.130.1.102 pmid:1727694 fatcat:zdreltjqqrekdpdfvbo5srd7ue