ANALYSIS OF SERUM SOLUBLE INTERFERON ^|^alpha;/^|^beta; RECEPTOR LEVELS IN PATIENTS WITH UROLOGICAL DISEASES
泌尿器科疾患における血清中可溶性インターフェロンα/βレセプターの意義

Hiro-omi Kanayama, Masayuki Takahashi, Masaaki Nishitani, Susumu Kagawa
2000 The Japanese Journal of Urology  
In order to define the clinical significance of serum soluble Interferon a/B receptor (sIFN a/BR) levels, we determined sIFN a/VR concentrations in serum of patients with urological benign and malignant diseases. (Materials and Methods) Serum sIFN a/13R levels were measured in normal control (n=22), patients with benign diseases (n=50) included urolithiasis (n=16), prostatic hypertrophy (n =13), and malignant diseases included bladder cancer (n=49), renal cell carcinoma (n=30) and prostate
more » ... r (n=36) by the enzyme linked immunosolbent assay (ELISA) using monoclonal and polyclonal antibodies. The levels of serum sIFN a/f3R was correlated with the results of other hematoserological examinations, and clinical or pathological characters of each urological malignancies. (Results) The serum sIFN a/BR levels (pg/ml) of patients with urolithiasis (2, 370. 6+640. 6, p =0. 0002), benign prostatic hypertrophy (2, 121. 1+550. 6, p=0. 0103), bladder cancer (2, 512. 3+1, 012. 3, p=0.0006), renal cell carcinoma (2, 686. 4+1, 510. 9, p=0.0046), prostate cancer (3, 188. 7+1, 788. 0, p= 0. 0003) showed significantly higher values than those of controls (1, 709. 5+346. 7). Moreover, we found statistically significant correlations among serum creatinine (Cr) levels and sIFN a/BR levels. However, there were no correlations between the sIFN a/f3R levels and clinical stage, or histological grade in the patients with bladder cancer or prostate cancer, whenever the levels of sIFN a/f3R were corrected by serum Cr levels. On the other hand, high level of corrected serum sIFN a/13R was observed in patients with high stage or high grade renal cell carcinoma, but not significant statistically. (Conclusions) Elevated serum sIFN a/f3R was observed in patients with urological disease. Further examinations should be necessary to determine the clinical usefulness of serum sIFN a/f3R.
doi:10.5980/jpnjurol1989.91.630 pmid:11068427 fatcat:ad5qhlwlrrad7bovsvxihapnga